Molecular Sieves
Apexbio Technology LLC Nutlin-3a chiral 675576-98-4 50mg
Nutlin-3a chiral (CAS 675576-98-4) is a small-molecule antagonist targeting mouse double minute 2 (MDM2) which functions as a negative regulator of the tumor suppressor TP53 By binding directly to the TP53-interacting pocket of MDM2 Nutlin-3a blocks the degradation of TP53 stabilizing the protein and activating TP53-dependent pathways Studies in solid tumors and lymphomas indicate that Nutlin-3a induces cell cycle arrest growth inhibition and apoptosis Research has demonstrated antitumor activity in vitro and in vivo highlighting its utility in studying TP53-related cell signaling pathways and its potential in cancer research applications
Selleck Chemical LLC SMI-4a
SMI-4a (TCS PIM-1 4a) is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serine/threonine- or tyrosine-kinases
Medchemexpress LLC Semaphorin-3A (SEMA3A) protein | >95.0% | 5 UG
Recombinant semaphorin-3A (SEMA3A) is a secreted axon guidance and cell-signaling protein supplied as a research reagent. The product is provided as a small purified preparation intended for in vitro assays, cell biology studies, and biochemical characterization. Purity is reported by the manufacturer as greater than 95% by reducing SDS-PAGE.
- Recombinant protein suitable for research use only.
- Expressed in HEK293 cells to support eukaryotic post-translational modifications.
- Fc-tagged format to aid detection and dimerization where applicable.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Supplied in a small, lyophilized preparation for convenient storage.
Apexbio Technology LLC TCS-PIM-1-4a 327033-36-3 100mg
TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
Chem-Impex International, Inc. Molecular sieves, 3?, beads 8-12 mesh | 1318-02-1 | MFCD00147627 | 5KG
Molecular sieves, 3?, beads 8-12 mesh, 1318-02-1, MFCD00147627, 5KG
Selleck Chemical LLC Dyngo-4a
Dyngo-4a is a potent dynamin inhibitor with IC50 of 0 38 M 1 1 M and 2 3 M for DynI (brain) DynI (rec) and DynII (rec) respectively